Isolated tumor cells in breast cancer
Purpose: The aim of the study was to explore the value of analyzing bone marrow BM for the presence of isolated tumor cell s ITCs in disease-free breast cancer patients 3 years after diagnosis. Experimental design: ITCs in BM at operation was found to be an independent prognostic factor in breast cancer patients. Among these, disease-free patients were analyzed with a second BM after 3 years follow-up median 40 months, SD 3 months, range At a median of 25 months since the second BM aspiration 66 months since diagnosis , 32 patients had developed relapse, 12 local and 20 systemic. Ten patients died of breast cancer.
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Natural product isolated from sea sponge tested against cancer cells
Background: The aim of this study was to determine the influence and significance of different aspiration sites and the number of mononuclear cells MNC analyzed on the frequency of isolated tumor cell ITC detection by immunocytochemistry ICC in BM aspirates from breast-cancer patients. Methods: BM aspirates were collected from the two anterior and two posterior crests just prior to primary surgery. In addition, a fraction of the pooled cells were further processed by negative immunomagnetic selection, for enrichment of ITC. Out of patients selected, 97 were further analyzed. Results: The ICC examination from the separate crests revealed 37 positive BMs from the anterior iliac crest and 30 positive from the posterior crest. Twenty-one of the samples were positive at both sides.
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Sentinel lymph node micrometastases and isolated tumor cells in breast cancer: An evolving field
The breast cancer TNM staging system is the most common way that doctors stage breast cancer. TNM stands for:. Your scans and tests give some information about the stage of your cancer. But your doctor might not be able to tell you the exact stage until you have surgery.
Dose-response curves of the first-line chemotherapeutic agents carboplatin and paclitaxel on tumor cells isolated from ascites of three patients. Oncotarget published " Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites " which reported that the authors aim is to determine the feasibility of cell proliferation assays of tumor cells isolated from malignant ascites to predict in vitro chemotherapy sensitivity, and to correlate these results with clinical outcome. In vitro sensitivity to chemotherapy was determined in cell proliferation assays using intracellular ATP content as an indirect measure of cell number.
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